The human brain remains plastic throughout the adult lifspan, even at older age. However, with increasing age that plasticity does undergo a decline. Our research group aims at a better understanding of adult cortical plasticity in different functional domains and how to facilitate such plasticity. We address this research question in several project areas with a combination of methods from neuroimaging, neuropsychology, physiology, and movement science. Although we examine human performance and its neurobiological basis during the whole lifespan, the relationships between sensory, motor and cognitive abilities, and the plastic adaptive capacities of older adults, are of particular interest for our research program.